This self-report questionnaire research aimed to investigate the effect of personal differences on perception of public safety, and to determine how perception of public safety impacts on individuals’ anxiety level and life satisfaction. Personal differences such as inferiority, family orientation, social cynicism, Chinese values, and crime victimization were included in this study. 182 local citizens in Macao (90 females and 92 males) who were aged 18 or above were recruited in this study. A self-administrated questionnaire was used to collect data. The data were analyzed by using the SPSS 18 statistical package. Results supported the vulnerability theory that inferiority has a negative correlation with perception of public safety; it also supported the social disorganization theory that social cynicism has a negative correlation with perception of public safety; it provided additional evidence that crime victimization is negatively related to and a strong predictor of perception of public safety; and it found that that Chinese values are positively related to perception of public safety. Results showed that perception of public safety is not significantly related to anxiety and life satisfaction. The implications of these findings and the limitations of this study were discussed.