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UM E-Theses Collection (澳門大學電子學位論文庫)

Title

基於生物技術的中藥藥效評價

English Abstract

Chinese medicine has a unique theoretical system and the exact effect, but because of the limitations of their own, the basic theory has not been widely recognized by the international scope. The modernization of traditional Chinese medicine (TCM) is an inevitable development trend, pharmacodynamic evaluation of Chinese medicine is one of the key. However, the theory of Chinese medicine and western medicine is essentially different, and the traditional means of Pharmacodynamic evaluation is not to suit Chinese medicine. With the development of the modern life sciences, genetic engineering techniques in biotechnology as the core made great progress, but also the pharmacodynamic evaluation of Chinese medicine to provide a new way of thinking and methods. Based on the existing major retrospective analysis of biotechnology, combined with the pharmacodynamic of Chinese medicine and the basic mechanism of material to explore the biology-based technology, discuss the project of pharmacological evaluation of Chinese medicine. Summarized through the collation of the literature and review of research on biotechnology applied to pharmacodynamic evaluation of Chinese medicine analysis and research on the modernization of traditional Chinese medicine a valuable reference work. This thesis is divided into six parts on: Chapter I, Introduction; the second chapter, an overview of biotechnology, as well as applications in medicine; Chapter III Evaluation of the efficacy of Chinese medicine, recalling research, research methods have been and so on; Chapter IV, Summary of analysis of biotechnology in medicine efficacy evaluation, including genetic engineering, cell engineering, protein engineering, etc; the fifth chapter, application of research, combined with traditional Chinese medicine in Sichuan Province in three cases of pharmaceutical companies to study the current problems of Chinese medicinal products to explore the introduction of biotechnology to improve the feasibility of the product; Chapter VI, the above research work, summed up the potential of biotechnology applications and prospects. Results of research on this topic will not only present the theory of traditional Chinese medicine research new ideas and methods, as well as Chinese medicine enterprises to improve product development and product to provide valuable reference. Key word: Biotechnology; Chinese medicine; Pharmacodynamic evaluation; Chinese medicine enterprises

Chinese Abstract

澳门大学硕士学位论文 基於生物技術的中藥藥效評價 摘要 中藥有著獨特的理論體系和確切的療效,但是由於自身的局限性,其基礎理 論還沒有得到國際範圍的廣泛認同。中藥的現代化是必然的發展趨勢,其中的關 鍵就是中藥的藥效評價。然而中藥與西藥理論有著本質的區別,傳統的藥效評價 手段不適用於中藥。隨著現代生命科學的發展,以基因工程技術為核心的生物技 術取得了巨大的進步,也為中藥的藥效評價提供了新的思路和方法。 本文通過對現有的主要生物技術進行回顧分析,結合中藥的藥效物質基礎和 作用機理,探討基於生物技術的中藥藥效評價這一課題。通過對文獻的歸納整理 和回顧研究,對生物技術應用於中藥藥效質量評價的情況進行分析,並且對中藥 現代化的研究工作提出有價值的參考。 本論文分為六個部分進行論述:第一章,前言;第二章,生物技術概述,以 及在中藥領域的應用;第三章,中藥藥效評價的研究,回顧研究現狀、已有的研 究方法等等;第四章,綜述分析生物技術在中藥藥效評價中的應用,包括基因工 程、細胞工程、蛋白質工程等等;第五章,應用現狀研究,結合四川省内三家中 藥制藥企業的情況,研究目前中藥產品存在的問題,探討引入生物技術進行產品 改進的可行性;第六章,綜合以上的研究工作,總結生物技術的應用潛力和前景。 本論文的研究成果既可以為目前中藥的理論研究提供新的思路和方法,也為 中國中藥企業的產品研發和產品改進提供有價值的參考。 關鍵詞:生物技術;中藥;藥效評價;中藥企業 4

Issue date

2009.

Author

謝元昊

Faculty
Institute of Chinese Medical Sciences
Degree

M.Sc.

Subject

Plant biotechnology

植物生物科技

Medicine, Chinese

中國醫藥

Supervisor

王一濤

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Location
1/F Zone C
Library URL
991005231059706306