Since Macau’s liberalization of the gaming industry rights in 2002, a large number of floating populations have emerged at casinos in Macau. This contributes to the increase in organized crime activity, and adds to the complexity of these crimes as gaming-related crime evolves in the casino. Gaming-related crimes went global with a lot of criminals from Mainland China. The Macau SAR government should not rely solely on the gaming company’s self monitoring. There is a need to strengthen appropriate scientific and technological equipment and personnel monitoring in the casino, in order to cope with the endless stream of the criminal operations (modus operandi). After Macau’s liberalization of the gaming industry rights, the related research topics have not been changed or systematically updated in time. With the development of Macau society, where violent crime gradually transformed into organized crime, that is economic crime based. Macau SAR needs to update and start new study in this field. This paper carries several research perspectives and suggests a healthy trend of development for next 10-years in the Macau gaming industry. Those suggestions are to plug the loopholes of casino lending and casino intermediaries of the legal system, to enhance the criminal intelligence exchange with neighboring regions, to coordinate with casino security intelligence exchange among the various casinos. Key Words: organized crime, gaming-related crime, loopholes, casino lending, casino intermediaries.