Ever since President Obama inauguration, he is sparing no efforts to advocate Asia-Pacific Rebalance strategy and put Asia-Pacific on a key position of US global strategy. Meanwhile, since its reform and opening-up, China has enjoyed rocketing economic growth and remarkable improvement on international influence, which starts to shake US’s dominating position in Asia-Pacific. US’s intention of maintaining hegemony and China’s rising as a potential threat go in line with Mearsheimer’s offensive realism theory. Rebalance strategy, which aims at maintaining US’s hegemony, conforms to Mearsheimer’s offensive realism, which seeks for hegemony via maximizing power. “The Belt and Road” (OBOR) strategy, which pursues economic integration and regional political cooperation, conforms to Mearsheimer’s idea that existence is the primary goal of great powers. This thesis first introduces the important theoretical source of this two strategies, offensive realism with emphasis on ideological system and characteristics. Then, it analyzes this two strategies respectively, including sources, motives and characteristics. From the perspective of strategic combination of theory and reality, this thesis explains the reasons and core of collision of the two strategies. Lastly, this thesis discusses potential challenges and opportunities the two strategies might have on China. The potential challenges include: firstly, compress China’s space for strategic maneuver; secondly, ignite China’s existing disputes with surrounding states; thirdly, break the military, economic and political balance in Asia-Pacific. Meanwhile, China will also enjoy some opportunities in the collision of both strategies: first of all, further boost China’s confidence in becoming a responsible and enterprising Asian state; in the next place, improve and enhance economic cooperation with states on the silk road and the maritime silk road; and then, output China’s traditional culture and enhance international influence and recognition; finally, enhance national defense and improve international discourse power