A simultaneous pressure drop and heat transfer experiment for single-phase flow in a plain and three micro-fin tubes was conducted in this study. The micro-fin tubes have the same fin height to inner diameter ratio of 0.0336, the same number of starts of 25, but different fin spiral angle of 18, 25 and 35. The transition of friction factor and heat transfer from laminar to turbulent were established and shown to be inlet dependent and fin spiral angle dependent. The results showed that the friction factor and heat transfer characteristics of the micro-fin tubes in the transition region were different compared to the plain tube. The friction factor and heat transfer data could not be easily correlated by the traditional regression method. Therefore, the logistic dose response curve fitting method, which has recently been used by other researchers in correlating the friction factor in plain tube, was proposed in this study for correlating the micro-fin tubes friction factor and heat transfer data. All the fully developed friction factor data for the entire flow regime can be predicted accurately by a composite logistic dose response function within ±18% deviation. The majority of the data (80%) was predicted with less than ±5% deviation. The fully developed ii heat transfer data for the entire flow regime were predicted by a composite logistic dose response function within ±28% deviation. The majority of the data (78%) was predicted with less than ±10% deviation.